Plant microRNA functions into human

2012/04/04 09:45:33

南京大学miRNA理论颠覆“转基因安全”神话，埋葬“实质等同性”原则，引世界轰动！ 核心提示： 南京大学张辰宇教授课题组一项非常令人惊奇的发现——植物的微小核糖核酸（microRNA）可以通过日常食物摄取的方式进入人体血液和组织器官。并且， 一旦进入体内，它们将通过调控人体内靶基因表达的方式影响人体的生理功能，进而发挥生物学作用。南京大学的miRNA理论发表以后引起世界极大关注，美国 老牌权威杂志《大西洋月刊》不得不发出惊呼：转基因食品确实具有非常真实的危险，会给人类的健康带来麻烦！ 这回真的是“麻烦大了”，因为转基因的生物被人类做了手脚后，牵一发会动全身，那么复杂的一个巨大系统，往里面插几个基因，算是“已知”的改动，会不会因 此多了或者少了几个microRNA？在新知的微小核糖核酸面前，转基因食品的安全性是不可能有保证的，因为干转基因、测转基因的那一套“严格的”规定， 根本就没有考虑微小核糖核酸。而肆意生产销售的转基因食品饲料对动物的杀伤力，已经被一再地证明了。那个只能骗骗傻子和官员的“小鼠7天灌胃”实验，无疑 已经永远钉在中国科技史的耻辱柱上了！ 转基因毒蛋白进入人体血液的机理，终于被揭开了！

Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA

Lin Zhang, Dongxia Hou, Xi Chen, Donghai Li, Lingyun Zhu, Yujing Zhang, Jing Li, Zhen Bian, Xiangying Liang, Xing Cai, Yuan Yin, Cheng Wang, Tianfu Zhang, Dihan Zhu, Dianmu Zhang, Jie Xu, Qun Chen, Yi Ba, Jing Liu, Qiang Wang, Jianqun Chen, Jin Wang, Meng Wang, Qipeng Zhang, Junfeng Zhang, Ke Zen and Chen-Yu Zhang

doi: 10.1038/cr.2011.158

Our previous studies have demonstrated that stable microRNAs (miRNAs) in mammalian serum and plasma are actively secreted from tissues and cells and can serve as a novel class of biomarkers for diseases, and act as signaling molecules in intercellular communication. Here, we report the surprising finding that exogenous plant miRNAs are present in the sera and tissues of various animals and that these exogenous plant miRNAs are primarily acquired orally, through food intake. MIR168a is abundant in rice and is one of the most highly enriched exogenous plant miRNAs in the sera of Chinese subjects. Functional studies in vitro and in vivo demonstrated that MIR168a could bind to the human/mouse low-density lipoprotein receptor adapter protein 1 (LDLRAP1) mRNA, inhibit LDLRAP1 expression in liver, and consequently decrease LDL removal from mouse plasma. These findings demonstrate that exogenous plant miRNAs in food can regulate the expression of target genes in mammals.

Comment 1

 食物掌控基因 ————人类培育的植物，可能也在改变着人类 《环球科学》2012年第1期, 作者：安娜•玛丽•C•霍奇（Anne-Marie C.Hodge） 冯泽君（翻译）