GWAS—–全基因组关联分析

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2011/02/07 15:29:35

GWAS在人类疾病的研究中非常热 门，但是在动植物的研究中却刚刚开始起步，正处在向人类GWAS方面进行借鉴的过程。但是GWAS对于动植物的研究可能将更加具有优势。由于动植物不像人 类那样可以随意构建群体以及随意重组。以下是到现今在动植物方面的gwas研究paper！

目前在动植物中应用到GWAS已经报道的物种包括拟南芥、小鼠、果蝇、水稻、牛、狗、猪。

拟南芥：

Genome-Wide Association Mapping in Arabidopsis Identifies Previously Known Flowering Time and Pathogen Resistance Genes. 2005 PLoS genetics

Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines.

2010 nature

小鼠：

Genome-wide association study and mouse model identify interaction between RET and EDNRB pathways in Hirschsprung disease. 2002 nature genetics

果蝇：

Genome-wide analysis of a long-term evolution experiment with Drosophila . 2010 nature

水稻：

Genome-wide association studies of 14 agronomic traits in rice landraces. 2010 nature genetics

牛：

A Validated Genome Wide Association Study to Breed Cattle Adapted to an Environment Altered by Climate Change. 2009 PLoS One

A validated genome-wide association study in 2 dairy cattle breeds for milk production and fertility traits using variable length haplotypes. 2009 Journal of Dairy Science

Genome-wide association study of growth in crossbred beef cattle. 2010 Journal Animal Science

Two-stage genome-wide association study identifies integrin beta 5 as having potential role in bull fertility. 2009 BMC genomics

狗：

Genome-wide association analysis of canine atopic dermatitis and identification of disease related SNPs. 2009 Immunogenetics

Genome-wide association mapping identifies multiple loci for a canine SLE-related disease complex. 2010 nature genetics

Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis. 2009 PNAS

猪：

A genome-wide association study on androstenone levels in pigs reveals a cluster of candidate genes on chromosome 6. 2010 BMC genetics